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MRCOG Part 1 – Genetics

Questions 1–5: Basic Genetics

The human diploid chromosome number is:

Answer: 46 (23 pairs)

Chromosomes are made up of:

Answer: DNA and histone proteins

A locus refers to:

Answer: Specific position of a gene on a chromosome

Alleles are:

Answer: Different forms of the same gene

Homozygous means:

Answer: Both alleles are identical

 

MRCOG Part 1 – Embryology

Questions 1–5: General Principles

Fertilization usually occurs in which part of the fallopian tube?

Answer: Ampulla

The zygote undergoes which type of cleavage after fertilization?

Answer: Holoblastic, rotational cleavage

Blastocyst hatches from which structure?

Answer: Zona pellucida

The inner cell mass of blastocyst gives rise to:

Answer: Embryo proper

The outer cell mass (trophoblast) forms:

Answer: Placenta

 

MRCOG Part 1 – Pharmacology

Questions 1–5: Drugs in Pregnancy

Which drug is used to induce labor by stimulating uterine contractions?

Answer: Oxytocin

Which drug is commonly used for tocolysis in preterm labor?

Answer: Nifedipine

Which drug is used to prevent seizures in eclampsia?

Answer: Magnesium sulfate

Which drug is contraindicated in pregnancy due to teratogenicity?

Answer: ACE inhibitors

Which prostaglandin analog is used for cervical ripening?

Answer: Misoprostol (PGE1)

 

MRCOG Part 1 – Pathology & Microbiology

Questions 1–5: General Pathology

Which type of necrosis is most commonly seen in ischemic limbs?

Answer: Coagulative necrosis

Which cell type is primarily involved in chronic inflammation?

Answer: Lymphocytes and macrophages

Granulomas are formed in response to:

Answer: Persistent antigen or foreign body

Which hypersensitivity reaction is responsible for autoimmune hemolytic anemia?

Answer: Type II (cytotoxic)

Which type of hypersensitivity is involved in SLE?

Answer: Type III (immune complex)

 

Questions 1–5: Female Reproductive Endocrinology

1.      Which hormone is responsible for the proliferation of endometrial glands in the follicular phase?
Answer: Estrogen

2.      Which hormone surge triggers ovulation?
Answer: LH (Luteinizing Hormone)

3.      Corpus luteum mainly secretes:
Answer: Progesterone and some estrogen

4.      Progesterone acts primarily on which endometrial layer?
Answer: Functional layer (secretory endometrium)

5.      FSH stimulates which ovarian cells to produce estrogen?
Answer: Granulosa cells

MRCOG Part 1 – Anatomy & Physiology Practice Questions

Questions 1–3: Female Reproductive Anatomy

  1. Which ligament connects the ovary to the lateral pelvic wall?
    • A) Broad ligament
    • B) Suspensory ligament of ovary
    • C) Round ligament
    • D) Ovarian ligament
      Answer: B) Suspensory ligament of ovary
  2. The uterine artery is a branch of which artery?
    • A) Internal iliac artery
    • B) External iliac artery
    • C) Ovarian artery
    • D) Abdominal aorta
      Answer: A) Internal iliac artery
  3. The endometrium is derived embryologically from:
    • A) Mesoderm
    • B) Ectoderm
    • C) Endoderm
    • D) Neural crest
      Answer: A) Mesoderm

MRCOG Part 1 – Statistics & Research

Questions 1–5: Basic Concepts

What is the mean of the numbers 2, 4, 6, 8, 10?

Answer: 6

What is the median of the numbers 3, 7, 9, 2, 5?

Answer: 5

Mode is defined as:

Answer: The value that occurs most frequently in a dataset

Variance measures:

Answer: Spread of data from the mean

Standard deviation is:

Answer: Square root of variance